The Journal of Organic Chemistry

Chemoenzymatic synthesis of 4-amino-2-hydroxy acids: a comparison of mutant and wild-type oxidoreductases

A Sutherland, CL Willis

文献索引：Sutherland, Andrew; Willis, Christine L. Journal of Organic Chemistry, 1998 , vol. 63, # 22 p. 7764 - 7769

全文：HTML全文

被引用次数: 32

摘要

We describe a new chemoenzymatic synthesis of enantiopure 4-amino-2-hydroxy acids using two biotransformations in a single-pot process in aqueous medium. These compounds are valuable as γ-turn mimics for investigations into the secondary structure of peptides. The enzyme substrates are a series of carbobenzyloxy (CBZ)-protected 4-amino-2-keto esters, prepared efficiently from the l-amino acids, alanine, leucine, phenylalanine, and valine. ...