Butyrophenones as hypotensive agents. Derivatives of 4-aryl-4-(hydroxymethyl) cyclohexylamine

D Lednicer, DE Emmert, AD Rudzik…

文献索引：Lednicer; Emmert; Rudzik; Graham Journal of Medicinal Chemistry, 1975 , vol. 18, # 6 p. 593 - 599

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被引用次数: 10

摘要

trituration of the residue with water gave a solid which was dried to yield 1.17 g (90.7%); TLC on alumina (microplate) with ether showed only the desired 26. This material was recrystallized from 2-propanol (15 ml) and dried to give 0.90 g (69.7%), mp 154-155'. Anal.(C27H3oNz) C, H, N. cis-and trans-2-(4, 4'-Difluorobenzhydryl)-3-formamido- quinuclidine (27). A solution of 6.0 g (0.0183 mol) of 2-(4, 4'-diflu-orobenzhydry1)-3-quin~ ...