Journal of the American Chemical Society

Highly a nti-Selective Catalytic Aldol Reactions of Amides with Aldehydes

S Saito, S Kobayashi

文献索引：Saito, Susumu; Kobayashi, Shu Journal of the American Chemical Society, 2006 , vol. 128, # 27 p. 8704 - 8705

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被引用次数: 97

摘要

Barium phenoxide-catalyzed, highly anti-selective direct-type aldol reactions of amides with aldehydes have been developed. In the presence of a slight excess amount of an amide, the desired reactions proceeded smoothly under mild conditions, and a wide range of aromatic, heterocyclic, α, β-unsaturated aldehydes were applicable to afford the desired adducts in high yields with high anti-selectivities. A catalytic, enantioselective reaction of an amide ...