Based on the knowledge that imidazoline can result in analgesic action due to its selective binding with the prostacyclin receptor, 20 1-oxyl-2-substitutedphenyl-4, 4, 5, 5- tetramethylimidazolines (3a–t) were prepared in moderate yields. At 0.13 mmol/kg dose, their in vivo analgesic activities were evaluated after the mice were administered at 30, 60, 90, and 150min. Compared with the pain threshold (12.27±9.56–17.71±7.00%) of normal ...
