Tetrahedron: Asymmetry

Chemoenzymatic synthesis of enantiomerically pure alkene 1, 2-diols and glycosides thereof

T Ziegler, F Bien, C Jurisch

文献索引：Ziegler, Thomas; Bien, Frank; Jurisch, Claus Tetrahedron Asymmetry, 1998 , vol. 9, # 5 p. 765 - 780

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被引用次数: 44

摘要

The kinetic resolution of racemic 2-O-acylated 3-butene-1, 2-diol and 1-O-acylated 3-butene- 1, 2-diol derivatives by enzymatic saponification and enzymatic esterification, respectively, is investigated with several lipases and esterases. The resulting partially blocked enantiomers are glycosylated with glycosyl halides and trichloroacetimidates, respectively.