Inhibitors of the FEZ-1 metallo-β-lactamase

…, LE Horsfall, M Galleni, JM Frère, CJ Schofield

文献索引：Lienard, Benoit M.R.; Horsfall, Louise E.; Galleni, Moreno; Frere, Jean-Marie; Schofield, Christopher J. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 4 p. 964 - 968

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被引用次数: 29

摘要

Metallo-β-lactamases (MBLs) catalyze the hydrolysis of β-lactams including penicillins, cephalosporins and carbapenems. Starting from benzohydroxamic acid (1) structure-activity studies led to the identification of selective inhibitors of the FEZ-1 MBL, eg, 2, 5-substituted benzophenone hydroxamic acid 17 has a Ki of 6.1±0.7 μM against the FEZ-1 MBL but does not significantly inhibit the IMP-1, BcII, CphA or L1 MBLs.