Potential antidepressants: 2-(methoxy-and hydroxyphenylthio) benzylamines as selective inhibitors of 5-hydroxytryptamine re-uptake in the brain

…, J Pomykáček, V Kmoníček, Z Šedivý…

文献索引：Jilek, Jiri; Sindelar, Karel; Pomykacek, Josef; Kmonicek, Vojtech; Sedivy, Zdenek; et al. Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 12 p. 3294 - 3338

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被引用次数: 30

摘要

Abstract 2-, 3-and 4Methoxythiophenol, and 2, 4-, 2, 5-and 3, 4-dimethoxythiophenol were transformed in two steps to the corresponding 2-(methoxyphenylthio) benzoyl chlorides XIII which were reacted with ammonia, methylamine, diethylamine, dipropylamine, and di (2- propyl) amine to give the amides XIV-XIX. These were reduced mostly with lithium aluminium hydride to the amines II-VII. These methoxylated amines were demethylated ...