Linear Synthesis of Chiral cycloSal??Pronucleotides

…, CA Román, JO Thomann, C Meier

文献索引：Morales, Edwuin Hander Rios; Roman, Cristina Arbelo; Thomann, Jens Oliver; Meier, Chris European Journal of Organic Chemistry, 2011 , # 23 p. 4397 - 4408

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被引用次数: 5

摘要

Abstract CycloSal-nucleosyl-phosphate triesters are a known class of highly effective nucleotide prodrugs (pronucleotides) of antivirally active nucleoside analogues. Until recently, the synthesis of these compounds always gave diastereoisomeric mixtures. Then, a convergent route for the stereospecific synthesis of cycloSal-triesters was described to give isomerically pure cycloSal-prodrugs for the treatment of viral diseases. Here, the ...