Asymmetric zinc-Reformatsky reaction of evans chiral imide with acetophenones and its application to the stereoselective synthesis of triazole antifungal agents
The Ni (acac) 2 catalytic ZnEt2-mediated asymmetric Reformatsky-type reaction of Evans chiral imide with various acetophenones was studied. The chiral imido zinc enolate, which was formed through the metal–halogen exchange reaction of chiral α-bromopropionyl-2- oxazolidinones 2 with diethyl zinc under the catalysis of Ni (acac) 2, performed the asymmetric zinc-Reformatsky reaction with activated α-haloacetophenones 3 to give the ...
![(4S)-5,5-diphenyl-4-isopropyl-3-[(2R,3R)-4-chloro-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-1-oxobutyl]-1,3-oxazolidin-2-one结构式](https://image.chemsrc.com/caspic/361/944472-98-4.png)
