The influence of stereochemistry and alkyl side chain length on the bioactivity of the Rho kinase inhibitor Y-27632 [(+)-1, R= Me] was examined by the synthesis of (+)-and (−)-1, and two alkyl chain analogs (+)-and (−)-2 (R= n-propyl) and (−)-3 (R= n-octyl) as well as their evaluation in enzymatic and neurite outgrowth assays.
![(R)-N-Boc-1-[4-(叔丁基二甲基甲硅烷基氧基甲基)环己基]乙烷-1-胺结构式](https://image.chemsrc.com/caspic/070/672314-58-8.png)
![(R)-N-[(4'-tert-butyldimethylsilyloxymethyl-cyclohexyl)methylidene]-1-phenylethanamine结构式](https://image.chemsrc.com/caspic/091/672314-40-8.png)
![(R)-1-[4-(tert-Butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine结构式](https://image.chemsrc.com/caspic/336/672314-51-1.png)