Spiro-Substituted Piperidines as Neurokinin Receptor Antagonists. II. Syntheses and NK2 Receptor-Antagonistic Activities of N-(2-Aryl-4-(spiro-substituted piperidin-1' …

H Kubota, A Kakefuda, H Nagaoka…

文献索引：Chemical and Pharmaceutical Bulletin, , vol. 46, # 2 p. 242 - 254

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被引用次数: 18

摘要

... Chemistry As shown in Chart 1, 3,4-dihydrospiro[1H-2-benzopy- ran—1,4'-piperidine] (8) was ... 1. Structures of SR48968 (1), GR159897 (2) and YM-35375 (3) (Q 1998 Pharmaceutical Society of Japan ... Chemical shifts are given in ppm relative to that of Me4Si (6:0) in CDC]3 or ...