Bioorganic & medicinal chemistry

Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs)

QH Chen, PNP Rao, EE Knaus

文献索引：Chen, Qiao-Hong; Praveen Rao; Knaus, Edward E. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 7898 - 7909

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被引用次数: 34

摘要

A group of 4-(4-methanesulfonylphenyl)-3-phenyl-2 (5H) furanones possessing an acetyl, 3- oxobut-1-ynyl,[hydroxyl (or alkoxy) imino] alkyl,[hydroxyl (or alkoxy) imino] alkynyl, and N- alkoxy (or N-phenoxy) carbonyl-N-hydroxy-N-ethylamino substituents at the para-position of the C-3 phenyl ring of rofecoxib were synthesized. This group of compounds was designed for evaluation as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs) ...