5-Alkyl-2-[(methylthiomethyl) thio]-6-(benzyl)-pyrimidin-4-(1H)-ones as potent non-nucleoside reverse transcriptase inhibitors of S-DABO series

…, C Mao, TK Venkatachalam, L Tuel-Ahlgren…

文献索引：Vig, Rakesh; Mao, Chen; Venkatachalam; Tuel-Ahlgren, Lisa; Sudbeck, Elise A.; Uckun, Fatih M. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 12 p. 1461 - 1466

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被引用次数: 59

摘要

Novel dihydroalkoxybenzyloxopyrimidine (S-DABO) derivatives targeting the non- nucleoside inhibitor (NNI) binding site of human immunodeficiency virus (HIV) reverse transcriptase (RT) have been synthesized using a novel computer model for the NNI binding pocket and tested for their RT inhibitory activity in cell-free assays using purified recombinant HIV RT as well as for their anti-HIV activity in HTL Viiib-infected peripheral ...