Synthesis and cytotoxicity of analogues of the antibiotic BE 10988 inhibitors of DNA topoisomerase II

…, B Pfeiffer, P Renard, L Dassonneville, C Bailly

文献索引：Catrycke, Marc-Olivier; Houssin, Raymond; Henichart, Jean-Pierre; Pfeiffer, Bruno; Renard, Pierre; Dassonneville, Laurent; Bailly, Christian Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 14 p. 2025 - 2030

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被引用次数: 9

摘要

Indolequinone derivatives of the antitumour antibiotic BE 10988 were synthesized and evaluated for their cytotoxicity and action mechanism. The quinone system is essential to biological activity and the thiazole ring plays a major role in the poisoning of topoisomerase II.