Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt's lymphoma

…, MT Larsen, S Sinning, DC Williams, HH Jensen

文献索引：Bright, Sandra A.; Brinko, Anne; Larsen, Maja Thim; Sinning, Steffen; Williams, D. Clive; Jensen, Henrik H. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1220 - 1224

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被引用次数: 4

摘要

We here report the synthesis of ethylene glycol N-interlinked imipramine dimers of various lengths from the tricyclic antidepressant desipramine via an amide coupling reaction followed by reduction with lithium aluminium hydride. The target molecules were found to be potent inhibitors of cellular viability while inducing cell type specific death mechanisms in three cancer cell lines including a highly chemoresistant Burkitt's lymphoma cell line. ...