Design, synthesis and antitumor activities of novel bis-aryl ureas derivatives as Raf kinase inhibitors

…, W Huang, Y Zhao, Z Yao, S Yu, S Yuan, F Jiang…

文献索引：Zhan, Wenhu; Li, Yanyang; Huang, Weiping; Zhao, Yanjin; Yao, Zhenglin; Yu, Shanyou; Yuan, Shoujun; Jiang, Falong; Yao, Shan; Li, Shuxin Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 14 p. 4323 - 4329

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被引用次数: 12

摘要

A series of novel bis-aryl ureas containing trifluoromethyl imidazolyl group targeting Raf kinase were designed and synthesized based on the lead compound of Sorafenib. All the prepared compounds were evaluated for their in vitro antiproliferative activities against three human cancer cell lines including MDA-MB-231 (breast), BGC-823 (gastric), and SMMC- 7721 (liver). Several compounds from the series exhibited excellent antitumor activities ...