(ω??2, ω??2, ω??3, ω??3)??Tetradeuterio??fatty acids for mechanistic studies of enzyme??catalyzed hydroxylation reactions

JH Horner, M Newcomb

文献索引：Horner, John H.; Newcomb, Martin Journal of Labelled Compounds and Radiopharmaceuticals, 2012 , vol. 55, # 11 p. 406 - 410

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被引用次数: 1

摘要

Among the thousands of cytochrome P450 enzymes known, many selectively hydroxylate the hydrocarbon tail of fatty acids at the terminal (v) position and the v-1, v-2, and v-3 positions. A general method for synthesis of (v-2, v-2, v-3, v-3)-tetradeuterio-fatty acids that can be used in mechanistic studies of cytochromes P450 is illustrated by the synthesis of 9, 9, 10, 10-tetradueteriododecanoic (lauric) acid and 13, 13, 14, 14- ...