Synthesis and nidation inhibitory activity of a new class of ergoline derivatives

E Brambilla, E Disalle, G Briatico, S Mantegani…

文献索引：Brambilla; Disalle; Briatico; Mantegani; Temperilli European Journal of Medicinal Chemistry, 1989 , vol. 24, # 4 p. 421 - 426

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被引用次数: 42

摘要

Abstract The synthesis and the nidation inhibitory activity (indirect evidence of prolactin activity) of a new class of ergolinyl-acylureas is described. Some structure—activity relationship considerations are also reported. N-[3-(Dimethyl-amino) propyl]-N-[(ethylamino) carbonyl]-6-(2-propenyl) ergoline-8β-carboxamide (laboratory code FCE 21336; international non-proprietary name cabergoline) was the most interesting compound of ...