The reactions of a series of phosphylating agents (RR'P (O) X) with ethanolamine have been examined, and relative yields of the products from the nucleophilic amino and hydroxyl moieties determined. In general the amount of O-phosphylation increased as R and R'were changed from dimethylamino through alkoxy to methyl and as the leaving group (X) was changed from OP (O) RR'to CN. The only exceptions occurred when R was dimethylamino ...
