The synthesis of immunomodulating peptide alloferon, the active principle of antiviral drug allokine-alpha

MV Sidorova, AS Molokoedov, EV Kudryavtseva…

文献索引：Sidorova; Molokoedov; Kudryavtseva; Baldin; Frid; Ovchinnikov; Bespalova; Bushuev Russian Journal of Bioorganic Chemistry, 2006 , vol. 32, # 2 p. 136 - 145

全文：HTML全文

被引用次数: 2

摘要

Abstract Two variants of the synthesis of tridecapeptide alloferon, the active principle of antiviral preparation allokine-alpha, were developed on the basis of fragment condensation in solution or on the Merrifield resin. The solid phase variant of the synthesis was shown to be more technological; it allows the preparation of the product at a higher total yield (40% vs. 17% for conventional synthesis in solution from the starting derivatives of the C-terminal ...