Tetrahedron letters

Solid-phase synthesis of fused [2, 1-b] quinazolinone alkaloids

A Kamal, N Shankaraiah, V Devaiah, KL Reddy

文献索引：Kamal, Ahmed; Shankaraiah; Devaiah; Reddy, K. Laxma Tetrahedron Letters, 2006 , vol. 47, # 51 p. 9025 - 9028

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被引用次数: 26

摘要

Solid-phase synthesis of fused [2, 1-b] quinazolinone alkaloids has been developed for the preparation of vasicinone and deoxyvasicinone by two approaches. The derivative of polymer-supported p-nitrophenyl carbonate was attached to anthranilic acid and then coupled with various bromo-lactams. This resin-linked bromo intermediate upon acetylation, hydrolysis and resin cleavage gave the cyclized [2, 1-b] quinazolinones (vasicinone). ...