Tetrahedron

New and highly efficient synthesis of 3-substituted 1-hydroxybenz [g] isoquinoline-5, 10-diones

…, S Claessens, BM Mbala, K Huygen, N De Kimpe

文献索引：Jacobs, Jan; Claessens, Sven; Mavinga Mbala, Blaise; Huygen, Kris; De Kimpe, Norbert Tetrahedron, 2009 , vol. 65, # 6 p. 1193 - 1199

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被引用次数: 17

摘要

A new and efficient strategy for the synthesis of 3-substituted 1-hydroxybenz [g] isoquinoline- 5, 10-diones by reaction of 2-methoxycarbonyl-1, 4-naphthoquinone with different pyridinium salts under Kröhnke conditions is disclosed. This one-step reaction was found to be dependent on the substitution pattern of the aromatic nucleus in the pyridinium salts.