Syntheses, radiolabelings, and in vitro evaluations of fluorinated PET radioligands of 5-HT6 serotoninergic receptors

J Colomb, G Becker, S Fieux, L Zimmer…

文献索引：Colomb, Julie; Becker, Guillaume; Fieux, Sylvain; Zimmer, Luc; Billard, Thierry Journal of Medicinal Chemistry, 2014 , vol. 57, # 9 p. 3884 - 3890

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被引用次数: 13

摘要

The 5-HT6 receptors are potent therapeutic targets for psychiatric and neurological diseases (schizophrenia, Alzheimer's disease, etc.). However, with lack of specific radiopharmaceuticals, their pharmacology is still incomplete and their exploration is limited to animal models. In this context, we have designed a fluorinated PET radiotracer,[18F] 2FNQ1P, that possesses a high affinity and selectivity for 5-HT6. In vitro PET ...