The Journal of organic chemistry

Mechanistic studies of Wacker-type intramolecular aerobic oxidative amination of alkenes catalyzed by Pd (OAc) 2/pyridine

X Ye, G Liu, BV Popp, SS Stahl

文献索引：Ye, Xuan; Liu, Guosheng; Popp, Brian V.; Stahl, Shannon S. Journal of Organic Chemistry, 2011 , vol. 76, # 4 p. 1031 - 1044

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被引用次数: 45

摘要

Wacker-type oxidative cyclization reactions have been the subject of extensive research for several decades, but few systematic mechanistic studies of these reactions have been reported. The present study features experimental and DFT computational studies of Pd (OAc) 2/pyridine-catalyzed intramolecular aerobic oxidative amination of alkenes. The data support a stepwise catalytic mechanism that consists of (1) steady-state formation of a PdII ...