Stereoselective total synthesis of etnangien and etnangien methyl ester

…, J Li, F Arikan, W Ahlbrecht, M Dieckmann…

文献索引：Li, Pengfei; Li, Jun; Arikan, Fatih; Ahlbrecht, Wiebke; Dieckmann, Michael; Menche, Dirk Journal of the American Chemical Society, 2009 , vol. 131, # 33 p. 11678 - 11679

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被引用次数: 69

摘要

A highly stereoselective joint total synthesis of the potent polyketide macrolide antibiotics etnangien and etnangien methyl ester was accomplished by a convergent strategy and proceeds in 23 steps (longest linear sequence). Notable synthetic features include a sequence of highly stereoselective substrate-controlled aldol reactions to set the characteristic assembly of methyl-and hydroxyl-bearing stereogenic centers of the ...