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Potential antiatherosclerotic agents. 2.(Aralkylamino)-and (alkylamino) benzoic acid analogs of cetaben

…, SA Schaffer, RG Shepherd, J Upeslacis

文献索引:Albright; DeVries; Largis; Miner; Reich; Schaffer; Shepherd; Upeslacis Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1378 - 1393

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被引用次数: 23

摘要

The syntheses of a series of (aralky1amino)-and (alky1amino) benzoic acids, as well as the corresponding esters and sodium salts, are described. The compounds were evaluated in vivo in rats for serum sterol and triglyceride lowering activity and in vitro for activity in inhibiting the principle cholesterol-esterifying enzyme of the arterial wall, fatty acyl-CoA: cholesterol acyltransferase (ACAT). Based on a combination of these two activities, ...

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