A novel Mannich-type reaction in aqueous media. Lanthanide triflate-catalysed condensation of aldehydes, amines and vinyl ethers for the synthesis of β-amino …

S Kobayashi, H Ishitani

文献索引：Kobayashi, Shu; Ishitani, Haruro Journal of the Chemical Society, Chemical Communications, 1995 , # 13 p. 1379 - 1380

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被引用次数: 82

摘要

The Mannich and related reactions provide one of the most fundamental and useful methods for the synthesis of (3-amino ketones. Although the classical protocols include some severe side reactions, new modifications using preformed iminium salts and imines have been developed.1 These materials are, however, often hygroscopic and are unstable at high tempera- tures. The direct synthesis of (3-amino ketones from aldehydes is desirable from ...