Diarylcyclobutane analogs of diethylstilbestrol

JE Lawson, RD Dennis, RF Majewski…

文献索引：Lawson,J.E. et al. Journal of Medicinal Chemistry, 1974 , vol. 17, p. 383 - 386

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被引用次数: 2

摘要

The ethylene unit connecting the phenolic rings of DES can be modified in many ways with retention of estrogenic activity. 5-7 It occurred to us that a cyclobutane ring might effectively replace that ethylene unit. A study of Dreiding models indicated that the aromatic rings and phenolic hydroxyl groups of either tram-1, 3-bis (p-hydroxyphenyl) cy-clobutane (tram-la) or tram-1, 2-bis (p-hydroxyphenyl) cy-clobutane (trans-2a) can be nearly superimposable ...