Route Selection and Process Development of a Multikilogram Route to the Inhaled A2a Agonist UK-432,097

CP Ashcroft, Y Dessi, DA Entwistle…

文献索引：Organic Process Research and Development, , vol. 16, # 3 p. 470 - 483

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被引用次数: 7

摘要

... Organic Process Research & Development. ... chloride 24 to give the ethyl ester 25 (Scheme 4). The chloride substrate 24 was prepared using the published procedure,(5c, 8b ... For Campaign 3, the process to 29 was outsourced, and 52 kg was received for subsequent processing. ...