Synthesis and antiproliferative activity of thiazolidine analogs for melanoma

W Li, Y Lu, Z Wang, JT Dalton, DD Miller

文献索引：Li, Wei; Lu, Yan; Wang, Zhao; Dalton, James T.; Miller, Duane D. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 15 p. 4113 - 4117

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被引用次数: 42

摘要

We have previously described 2-aryl-thiazolidine-4-carboxylic acid amides as a novel class of antiproliferative agents for prostate cancer. Screening these compounds with melanoma cell lines revealed that several of them have potent antiproliferative activity and selectivity against melanoma. To further improve the potency and selectivity, we synthesized a new series of analogs and tested them in two melanoma cell lines and fibroblast cells ( ...