Synthesis of the Sialyl Lewis X Epitope Attached to Glycolipids with Different Core Structures and their Selectin??Binding Characteristics in a Dynamic Test System

C Gege, J Vogel, G Bendas, U Rothe…

文献索引：Gege, Christian; Vogel, Jan; Bendas, Gerd; Rothe, Ulrich; Schmidt, Richard R. Chemistry - A European Journal, 2000 , vol. 6, # 1 p. 111 - 122

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被引用次数: 46

摘要

Abstract Sialyl Lewis X (sLe X)/selectin-mediated leukocyte rolling along endothelial cells has recently gained wide interest. In this paper the influence of the spacer length of laterally clustered neoglycolipids 1 ad on cell rolling in a dynamic test system is investigated. The required di-O-hexadecyl glycerols with none, and with three, six, or nine ethylene glycol units as spacer groups (compounds 4 ad) could be readily obtained. The synthesis of 1-O- ...