Discovery and SAR development of 2-(phenylamino) imidazolines as postacyclin receptor antagonists

…, A Jahangir, D Severance, R Salazar, T Chang…

文献索引：Clark, Robin D.; Jahangir, Alam; Severance, Daniel; Salazar, Rick; Chang, Thomas; Chang, David; Jett, Mary Frances; Smith, Steven; Bley, Keith Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 4 p. 1053 - 1056

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被引用次数: 52

摘要

On the basis of screening hits (1a, b), a series of selective, high affinity prostacyclin receptor antagonists was developed. The optimized lead compound 25d [(4, 5-dihydro-1H-imidazol-2- yl)-[4-(4-isopropoxybenzyl) phenyl] amine] had analgesic activity in the rat.