Ring transformation of pyrimidines to pyridines. Synthesis of 4??alkylaminopyridin??2??ones by alkaline hydrolysis of 6??(2??dimethylaminovinyl) uracils
Abstract Alkaline hydrolysis of 1, 3-disubstituted 6-(2-dimethylaminovinyl) uracils 2 induced a novel ring transformation giving 4-alkylaminopyridin-2-ones 3 via ring-opening and ring- closure processes. The 4-methylamino-3-nitropyridin-2-one (3a) thus obtained was employed for the synthesis of 3-deazahypoxanthine derivative 8. 4-Alkylamino-3- cyanopyridin-2-ones 11, ricinine analogs, were also prepared by the reaction of 4-chloro- ...
![6-[(E)-2-(dimethylamino)vinyl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile结构式](https://image.chemsrc.com/caspic/366/116705-33-0.png)
