Tetrahedron letters

Synthesis and reactions of cyclopentadiene monoaziridine: a concise approach to the core of agelastatin A

E Baron, P O'Brien, TD Towers

文献索引：Baron, Elise; O'Brien, Peter; Towers, Timothy D Tetrahedron Letters, 2002 , vol. 43, # 4 p. 723 - 726

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被引用次数: 39

摘要

An improved protocol for the preparation of cyclopentadiene monoaziridine is described (88% yield). The utility of cyclopentadiene monoaziridine is demonstrated by its use in (i) the shortest synthetic entry into 4-amino substituted cyclopentenes and (ii) the preparation of two key intermediates in a concise synthetic approach to the cyclopentane core of agelastatin A. The agelastatin A model studies make use of a lithium amide-mediated ...