Rapid and Efficient Synthesis of High-Purity Fluorine-18 Labeled Haloperidol and Spiperone via the Nitro Precursor in Combination with a New HPLC Separation …

K Hashizume, N Hashimoto, Y Miyake

文献索引：Hashizume, Kazunari; Hashimoto, Naoto; Miyake, Yoshihiro Bulletin of the Chemical Society of Japan, 1997 , vol. 70, # 3 p. 681 - 687

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被引用次数: 5

摘要

We have completed a convenient synthesis of fluorine-18 labeled butyrophenone neuroleptics from their nitro precursors. Thus, we have developed an efficient single-column HPLC system using a C 18-bonded vinyl alcohol copolymer gel (octadecyl polymer, ODP) column and strongly alkaline solvent systems for purifying of the 18 F-labeled butyrophenone neuroleptics obtained by a single-step 18 F-for-nitro exchange reaction. ...