Tetrahedron

Synthesis of 2, 3, 4, 7-tetrahydro [1, 4] thiazepines from thiazolidines and β-enaminonitriles

…, A González-Ortega, R Marcos, M Pérez, MC Sanudo

文献索引：Calvo, Luis A.; Gonzalez-Ortega, Alfonso; Marcos, Rocio; Perez, Monica; Sanudo, M. Carmen Tetrahedron, 2008 , vol. 64, # 17 p. 3691 - 3700

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被引用次数: 16

摘要

A wide library of 2, 3, 4, 7-tetrahydro [1, 4] thiazepines have been prepared by simple heating of thiazolidine and β-enaminonitrile derivatives in acetonitrile. The procedure, whose yields depend on the nature and position of the substituents, gave good results if the substituents were not very bulky but it is less effective when starting from 2-substituted thiazolidines.