Design, synthesis and biological activities of some 7-aminocephalosporanic acid derivatives

…, A Demirbas, S Ulker, S Alpay-Karaoglu…

文献索引：Basoglu, Serap; Demirbas, Ahmet; Ulker, Serdar; Alpay-Karaoglu, Sengul; Demirbas, Neslihan European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 622 - 631

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被引用次数: 11

摘要

Abstract The treatment of 7-ACA with 4-substituted benzensulfonyl chlorides afforded the compounds containing 4-nitro/aminophenyl sulfonylamino moiety in the cephalosporanic acid skeleton (2, 4). The synthesis of the cephalosporanic acid derivatives containing 1, 3- thiazole or 5-oxo-1, 3-thiazolidine nucleus and sulfonamide function (8a, 8b, 10) was performed starting from 7-ACA by several steps. The reaction of 7-ACA with [4-(2-fluoro-4- ...