Tetrahedron letters

The Heck–Matsuda arylation of 2-hetero-substituted acrylates

F De Azambuja, CRD Correia

文献索引：De Azambuja, Francisco; Correia, Carlos Roque Duarte Tetrahedron Letters, 2011 , vol. 52, # 1 p. 42 - 45

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被引用次数: 10

摘要

The Heck–Matsuda arylation of 2-aza and 2-oxo-substituted acrylates is described. Several reaction conditions were evaluated including the influence of solvents, temperature, catalysts, and stoichiometry. While the oxygenated system was successfully arylated in benzonitrile with Pd2 (dba) 3 as catalyst, the aza-acrylate furnished methoxylated products. The methoxylated products were subjected to an elimination/reduction protocol to obtain ...