Microwave-enhanced synthesis of 2, 3, 6-trisubstituted pyridazines: application to four-step synthesis of gabazine (SR-95531)

N Gavande, GAR Johnston, JR Hanrahan…

文献索引：Gavande, Navnath; Johnston, Graham A. R.; Hanrahan, Jane R.; Chebib, Mary Organic and Biomolecular Chemistry, 2010 , vol. 8, # 18 p. 4131 - 4136

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被引用次数: 14

摘要

Microwave-enhanced, highly efficient protocols for the synthesis of synthetically and biologically important 2, 3, 6-trisubstituted pyridazine architectures have been developed by sequential amination/Suzuki coupling/alkylation reactions. This powerful strategy is an economical and highly chemoselective protocol for the synthesis of diversified pyridazines. The total synthesis of gabazine (SR-95531) has been achieved using a versatile strategy ...