Advanced aqueous-phase phosphoramidation reactions for effectively synthesizing peptide–oligonucleotide conjugates trafficked into a human cell line

…, YC Su, EC Wang, S Severance, CC Hwang…

文献索引：Wang, Tzu-Pin; Ko, Ni Chien; Su, Yu-Chih; Wang, Eng-Chi; Severance, Scott; Hwang, Chi-Ching; Shih, Ying Ting; Wu, Min Hui; Chen, Yen-Hsu Bioconjugate Chemistry, 2012 , vol. 23, # 12 p. 2417 - 2433

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被引用次数: 11

摘要

Peptide–oligonucleotide conjugates (POCs) have held promise as effective therapeutic agents in treating microbial infections and human genetic diseases including cancers. In clinical applications, POCs are especially useful to circumvent cellular delivery and specificity problems of oligonucleotides. We previously reported that nucleic acid phosphoramidation reactions performed in aqueous solutions have the potential for facile ...