Tetrahedron letters

New solid phase synthesis of oligodeoxythymidine phosphorodithioates by a modified HObt-method

AB Eldrup, J Felding, J Kehler, O Dahl

文献索引：Eldrup, Anne B.; Felding, Jakob; Kehler, Jan; Dahl, Otto Tetrahedron Letters, 1995 , vol. 36, # 34 p. 6127 - 6130

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被引用次数: 5

摘要

Two new dithiophosphorylating reagents 2a, b have been prepared and shown to give nucleoside monomers 3a, b with reactivities suitable for solid phase synthesis. An octamer and a nonamer deoxythymidine phosphorodithioate were prepared on a TentaGel support with good coupling efficiencies. The products after deblocking are free from phosphorothioate contaminations (detection limit 0.5%).