The neighboring group effect of fluorine in the tritium labeling of organic substrates with [Cp*(PMe3) IrMe (CH2Cl2)]+[BArf]−, a cationic iridium (III) complex

MB Skaddan, RG Bergman

文献索引：Skaddan, Marc B.; Bergman, Robert G. Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 7 p. 623 - 634

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被引用次数: 13

摘要

Abstract The cationic Ir (III) complex,[Cp*(PMe 3) IrMe (CH 2 Cl 2)][BAr f](1, Cp*= η 5-C 5 Me 5, BAr f= MeB (C 6 F 5) 3), has been shown to be a useful reagent in the tritium and deuterium labeling of organic substrates. During a recent reaction of 1 with a fluorinated molecule, we observed an unusually high incorporation of tritium ortho to the aromatic fluorines. To probe whether this was an isolated incident or a more general phenomenon, ...