Tetrahedron letters

A real time reaction monitoring using fluorescent dansyl group as a solid-phase leaving group

T Suenaga, C Schutz, T Nakata

文献索引：Suenaga, Toshiro; Schutz, Caroline; Nakata, Tadashi Tetrahedron Letters, 2003 , vol. 44, # 31 p. 5799 - 5801

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被引用次数: 6

摘要

A real time monitoring method to monitor the progress of the solid-phase reaction has been developed. The substitution reaction on the solid-phase was clearly monitored as a change in the color depth using the fluorescent dansyl group as the leaving group. This methodology is applicable to both parallel and split combinatorial synthesis.