Antiproliferative activity of Rhinacanthus nasutus (L.) Kurz extracts and the active moiety, rhinacanthin C

A Gotoh, T Sakaeda, T Kimura, T Shirakawa…

文献索引：Gotoh, Akinobu; Sakaeda, Toshiyuki; Kimura, Takashi; Shirakawa, Toshiro; Wada, Yoshitaka; Wada, Atsushi; Kimachi, Tetsutaro; Takemoto, Yoshiji; Iida, Akira; Iwakawa, Seigo; Hirai, Midori; Tomita, Hisako; Okamura, Noboru; Nakamura, Tsutomu; Okumura, Katsuhiko Biological and Pharmaceutical Bulletin, 2004 , vol. 27, # 7 p. 1070 - 1074

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被引用次数: 47

摘要

Rhinacanthus nasutus (L.) KURZ (Acanthaceae) is a shrub widely distributed in South China and India. In this study, the antiproliferative activity of the ethanol extract of root and aqueous extract of leaves of R. nasutus, and the supposed active moiety rhinacanthin C was assessed in vitro using the human cervical carcinoma cell line HeLa, its MDR1- overexpressing subline Hvr100-6, human prostate carcinoma PC-3 cells and human ...