Tetrahedron Letters

A facile synthesis of 7-amino-3-desacetoxycephalosporanic acid derivatives by indium-mediated reduction of 3-iodomethylcephems in aqueous media

H Chae, S Cho, G Keum, SB Kang, AN Pae, Y Kim

文献索引：Chae, Hyungsun; Cho, Sangwon; Keum, Gyochang; Kang, Soon Bang; Pae, Ae Nim; Kim, Youseung Tetrahedron Letters, 2000 , vol. 41, # 20 p. 3899 - 3901

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被引用次数: 21

摘要

An efficient reductive conversion of 3-iodomethylcephalosporin and 3- acetoxymethylcephalosporin derivatives mediated by indium into the corresponding 3- methylcephems and 3-methylenecephams in moderate to good yields has been developed in an aqueous system. 3-Methylenecephams are converted into the corresponding 3- methylcephems under previously reported basic conditions quantitatively.