Preparation of 2??phenyl??2??hydroxymethyl??4??oxo??1, 2, 3, 4??tetrahydroquinazoline and 2??methyl??4??oxo??3, 4??dihydroquinazoline derivatives formation

P Hradil, L Kvapil, J Hlaváč, TŠ Weidlich…

文献索引：Hradil; Kvapil; Hlavac; Weidlich; Lycka; Lemr Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 4 p. 831 - 837

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被引用次数: 15

摘要

Abstract The cyclization of phenacyl anthranilate has been studied with the aim to develop the synthesis of 2-(2′-aminophenyl)-4-phenyloxazole. However, a different course of the reaction than expected was observed. 2-Phenyl-2-hydroxymethyl-4-oxo-1, 2, 3, 4- tetrahydroquinazoline (3a) was formed by the reaction of phenacyl anthranilate (2) with ammonium acetate under various conditions.