... Chem. ... Table 2, entry 5). Interestingly, when n-butanol was used as a solvent, the highly active 2-chloropyrimidine preferably underwent an S N Ar ... c Average of two runs, products were isolated via column-chromatography (silica (20 × 3 cm), cyclohexane:EtOAc:NEt 3 (10:1:1) as ...