Abstract A series of novel 2, 5-disubstituted 1, 3, 4-oxadiazin-6-ones and their N- aroylhydrazone precursors were synthesized and characterized by NMR and UV–Vis spectroscopy. The electronic properties of 2-aryl-5-phenyl-1, 3, 4-oxadiazin-6-ones are mainly dependent on the 2-aryl substituent and their absorption maxima exhibit a red shift in dichloromethane. Single crystal X-ray diffraction on four acylhydrazones indicated the ...