Adrenal medulla imaging agents: a structure-distribution relationship study of radiolabeled aralkylguanidines

…, TJ Mangner, MN Inbasekaran, LE Brown…

文献索引：Wieland; Mangner; Inbasekaran; Brown; Wu Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 149 - 155

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被引用次数: 40

摘要

Fourteen 12SI-labeled aralkylguanidines were synthesized and evaluated as potential imaging agents for the adrenal medullae and tumors of adrenomedullary origin. These guanidines are radiotracer analogues of guanethidine, an antihypertensive agent thought to mediate neuron blockade by uptake into adrenergic nerves. Dog adrenal medullae were used as a model to test radiotracer affinity for catecholamine storage tissue. Tissue ...