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Resolution of a racemic Corey lactone via enantioselective esterification

I Veselý, J Paleček, I Stibor

文献索引:Vesely, Ivan; Palecek, Jaroslav; Stibor, Ivan Collection of Czechoslovak Chemical Communications, 1992 , vol. 57, # 2 p. 357 - 361

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被引用次数: 1

摘要

Abstract The (-)-enantiomer of Corey lactone Ia has been separated from its (+)-enantiomer Ib via enantioselective esterification of the latter using glycerol tributyrate and catalytic amount of lipase from Candida cylindracea (EC 3.1. 1.3) in an aprotic solvent at 20 to 40 C during 5 to 48 h. The Ic obtained has been separated from Ia by column chromatography and converted back to Ib by acid catalyzed transesterification with methanol.